Could Licorice prevent Bisphenol A-Induced Biochemical, Histopathological and Genetic Effects in the Adult Male Albino Rats?

Document Type : Original Article

Authors

1 Department of Pharmacology, Faculty of Medicine, Minia University, Minia, Egypt.

2 Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Minia University, Minia, Egypt.

3 Department of Cell Biology, National Research Centre, Egypt

Abstract

Bisphenol A (BPA) is an ecological estrogenic endocrine disruptor used commonly in polycarbonate plastics. This study aimed to investigate the biochemical, histopathological and genetic effects of BPA at different doses and to evaluate the protective role of licorice against such effects. Thirty Wistar male albino rats were divided into five groups administered BPA daily at 2.4 µg/kg and 500 mg/kg orally with or without licorice (150 mg/kg) for 4 weeks. The results revealed that the high toxic dose decreased GSH, SOD and catalase levels and increased MDA level significantly. Serum TNF-α, testosterone and testicular cholesterol levels were significantly decreased while serum alkaline phosphatase was significantly increased. Histopathological changes were observed in testes, lungs and stomach. Alteration in the expression of NF-κB1 gene in lung occurred. These results suggested that BPA induced oxidative stress; resulted in its complication in the examined rats and treatment with licorice alleviated the toxicity induced by BPA.

Keywords

Ain Shams Journal of Forensic Medicine and Clinical Toxicology
Volume 30, Issue 1
January 2018
Pages 73-87

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