The Potential Impact of Magnesium Supplementation on Cisplatin-Induced Nephrotoxicity in Adult Male Albino Rats

Document Type : Original Article


1 Department of Forensic Medicine and Clinical Toxicology,Faculty of Medicine, Tanta University, Tanta, Egypt

2 Department of Pathology,Faculty of Medicine, Tanta University, Tanta, Egypt.

3 Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Zagazig University, Al sharqia , Egypt.


Background: Cisplatin has been considered one of the most effective chemotherapeutic agents. It is associated with numerous toxicities at therapeutic doses like ototoxicity, gastrotoxicity, myelosuppression, allergic reactions and nephrotoxicity. The synergistic effects of Cisplatin and magnesium deficiency are believed to contribute to renal dysfunction. Aim:The aim of this study was to study the nephrotoxicity of cisplatin and evaluate potential impact of magnesium supplementation on such toxicity. Materials and Methods: Thirty-two adult male albino rats were divided into four equal groups. Group I served as (Control group). Group II (magnesium treated group) received single injection of magnesium sulphate (90mg/kg), Groups III (Cisplatin treated group) received single injection of 5 mg/kg body weight of cisplatin and Group IV (Cisplatinand magnesium treated group) received single injection of 90mg/kg magnesium sulphate and 5mg of cisplatin. After 14 days,biochemical parameters in serum were studied: creatinine,BUN, magnesium andinflammatory marker (IL-6) levels.Kidneyswere examined by light microscope as well. Results: results indicated that: serum levels of the creatinine,IL-6 and BUN of treated rats showeda highly significantincreased compared to control animals, whereas serum magnesium showedhighly significantdecreased.Magnesiumsupplementationreverse these chages. In conclusion:Our study demonstrated that cisplatin induced andomized in the kidney function andMg supplementation ameliorates it. It is recommendedto do further investigations to determine therole of magnesium in cisplatin induced nephrotoxicity.