Hair dyes are widely used as cosmetic agents to color the grey hair around the world. P-phenylenediamine (PPD) induced genotoxicity due to dermal application was investigated in this study. 90 rats conducted this study and were classified into main 4 groups. Negative control group, positive control group. In-addition, two toxicity groups; short term toxicity group and long term toxicity group. Both toxicity groups were further subdivided according to PPD dose into 10 and 15 mg/kg subgroups. The results showed that repeated dermal exposure to PPD induced significant DNA damage in peripheral blood lymphocytes in dose and time dependent manner.
AlSeigini, A., ElSayed, A., ElHelaly, H., & Abdelhakim, E. (2014). Assessment of DNA Damage on Adult Albino Rats Induced by Dermal Exposure to P-Phenylenediamine (PPD). Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 23(2), 173-181. doi: 10.21608/ajfm.2014.18763
MLA
Ahmed AlSeigini; Amany ElSayed; Hend ElHelaly; Eman Abdelhakim. "Assessment of DNA Damage on Adult Albino Rats Induced by Dermal Exposure to P-Phenylenediamine (PPD)", Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 23, 2, 2014, 173-181. doi: 10.21608/ajfm.2014.18763
HARVARD
AlSeigini, A., ElSayed, A., ElHelaly, H., Abdelhakim, E. (2014). 'Assessment of DNA Damage on Adult Albino Rats Induced by Dermal Exposure to P-Phenylenediamine (PPD)', Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 23(2), pp. 173-181. doi: 10.21608/ajfm.2014.18763
VANCOUVER
AlSeigini, A., ElSayed, A., ElHelaly, H., Abdelhakim, E. Assessment of DNA Damage on Adult Albino Rats Induced by Dermal Exposure to P-Phenylenediamine (PPD). Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2014; 23(2): 173-181. doi: 10.21608/ajfm.2014.18763
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