Studying the Protective Effect of N-acetyl cysteine and Lcarnitine on Testicular Toxicity Induced by Valproic Acid Administration in Adult Male Albino Rats
Introduction: Sodium valproate (VPA) is a well-known antiepileptic drug used in treatment of generalized seizures and cause many toxic effects. Aim: This study aimed to highlight the VPA effects on testes in adult male albino rats and protective effect of N- acetyl cysteine (NAC) and L-carnitine. Methodology: Sixty adult male albino rats divided into six groups randomly, 10 rats each, group I: negative control group not received any treatment. group II: positive control group received NAC 150 mg/kg/day orally, group III: positive control group received Lcarnitine 500 mg/kg/day orally, group IV: received VPA 400 mg/kg/day orally which equals 40/67 of Ld50 of valproic acid in rats, group V: received VPA 400 mg/kg and NAC 150 mg/kg daily orally, group VI: received VPA 400 mg/kg and L-carnitine 500 mg/kg daily orally for 45 days. Results: This study revealed high significant difference between group received VPA (IV) in form of marked decrease in serum testosterone compared to control groups (I, II, III), laboratory parameters are co-incident with histopathological findings in testes of these groups. We found a significant improvement in laboratory parameters in the form of higher serum testosterone levels in groups received antioxidants with VPA (V, VI), co-incident with histopathological findings in testes of these groups, with a higher protective power of Lcarnitine than N- acetyl cysteine. Conclusion: Sodium valproate induces testicular toxicity in high doses (400 mg/kg) in male albino rats. There is a protective role for both NAC and Lcarnitine. L-carnitine exhibited more protective effect than NAC on their administration with VPA.
Received in original form: 30 March 2023 Accepted in a final form: 24 May 2023
Said, A., Yassin, S., Mohammad, S., Muhammad, E., Abdelnaby, A., & Ali, W. (2023). Studying the Protective Effect of N-acetyl cysteine and Lcarnitine on Testicular Toxicity Induced by Valproic Acid Administration in Adult Male Albino Rats. Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 41(2), 24-32. doi: 10.21608/ajfm.2023.308116
MLA
Ahmed Said; Sara Yassin; Soheir Mohammad; Eman Muhammad; Amira Abdelnaby; Wafaa Ali. "Studying the Protective Effect of N-acetyl cysteine and Lcarnitine on Testicular Toxicity Induced by Valproic Acid Administration in Adult Male Albino Rats", Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 41, 2, 2023, 24-32. doi: 10.21608/ajfm.2023.308116
HARVARD
Said, A., Yassin, S., Mohammad, S., Muhammad, E., Abdelnaby, A., Ali, W. (2023). 'Studying the Protective Effect of N-acetyl cysteine and Lcarnitine on Testicular Toxicity Induced by Valproic Acid Administration in Adult Male Albino Rats', Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 41(2), pp. 24-32. doi: 10.21608/ajfm.2023.308116
VANCOUVER
Said, A., Yassin, S., Mohammad, S., Muhammad, E., Abdelnaby, A., Ali, W. Studying the Protective Effect of N-acetyl cysteine and Lcarnitine on Testicular Toxicity Induced by Valproic Acid Administration in Adult Male Albino Rats. Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2023; 41(2): 24-32. doi: 10.21608/ajfm.2023.308116
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