• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Peer Review Process
  • Guide for Authors
  • Submit Manuscript
  • Reviewers
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter
Ain Shams Journal of Forensic Medicine and Clinical Toxicology
arrow Articles in Press
arrow Current Issue
Journal Archive
Volume Volume 39 (2022)
Issue Issue 2
Volume Volume 38 (2022)
Volume Volume 37 (2021)
Volume Volume 36 (2021)
Volume Volume 35 (2020)
Volume Volume 34 (2020)
Volume Volume 33 (2019)
Volume Volume 32 (2019)
Volume Volume 31 (2018)
Volume Volume 30 (2018)
Volume Volume 29 (2017)
Volume Volume 28 (2017)
Volume Volume 27 (2016)
Volume Volume 26 (2016)
Volume Volume 25 (2015)
Volume Volume 24 (2015)
Volume Volume 23 (2014)
Volume Volume 22 (2014)
Volume Volume 21 (2013)
Volume Volume 20 (2013)
Volume Volume 19 (2012)
Elbastawesy, S., Ibrahim, F., Abo Safia, H., El Shamy, A., Ibrahim, H., Helal, N. (2022). Nephrotoxic effect of Hydrogen Cyanamide (Dormex) and possible protective role of N-acetyl cysteine in male albino rats. Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 39(2), 21-29. doi: 10.21608/ajfm.2022.244112
Samah Elbastawesy; Fatma Ibrahim; Hend Abo Safia; Amira El Shamy; Hoda Ibrahim; Nadia Helal. "Nephrotoxic effect of Hydrogen Cyanamide (Dormex) and possible protective role of N-acetyl cysteine in male albino rats". Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 39, 2, 2022, 21-29. doi: 10.21608/ajfm.2022.244112
Elbastawesy, S., Ibrahim, F., Abo Safia, H., El Shamy, A., Ibrahim, H., Helal, N. (2022). 'Nephrotoxic effect of Hydrogen Cyanamide (Dormex) and possible protective role of N-acetyl cysteine in male albino rats', Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 39(2), pp. 21-29. doi: 10.21608/ajfm.2022.244112
Elbastawesy, S., Ibrahim, F., Abo Safia, H., El Shamy, A., Ibrahim, H., Helal, N. Nephrotoxic effect of Hydrogen Cyanamide (Dormex) and possible protective role of N-acetyl cysteine in male albino rats. Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2022; 39(2): 21-29. doi: 10.21608/ajfm.2022.244112

Nephrotoxic effect of Hydrogen Cyanamide (Dormex) and possible protective role of N-acetyl cysteine in male albino rats

Article 3, Volume 39, Issue 2, July 2022, Page 21-29  XML PDF (1.69 MB)
Document Type: Original Article
DOI: 10.21608/ajfm.2022.244112
Authors
Samah Elbastawesyorcid 1; Fatma Ibrahimorcid 2; Hend Abo Safiaorcid 2; Amira El Shamy3; Hoda Ibrahimorcid 3; Nadia Helal1
1Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
2Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
3Medical Biochemistry and molecular biology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Abstract
Background: Dormex is a highly toxic fertilizer that causes local tissue irritation in addition to multiple organ toxicity mainly through oxidative stress. Aim of the study: This study aimed to investigate nephrotoxic effect of dormex and to evaluate potential protective role of N-acetyl cysteine (NAC) on kidney of male albino rats. Methods: This study was conducted on forty mature male albino rats were distributed to; Group I, II: rats were given normal saline and NAC, respectively. Group III: rats received single dose of dormex. Group IV: rats were given the same dose of dormex plus NAC. Blood urea and serum creatinine were assessed. Oxidative stress markers as malondialdehyde (MDA), catalase, reduced glutathione and superoxide dismutase (SOD ) were measured. Renal specimens were studied with hematoxylin and eosin. Results: Renal indices, urea and creatinine, MDA were significantly increased, while glutathione reductase, catalase and glutathione peroxidase were lowered significantly in experimental rats received dormex. Kidney tissue of dormex administered rat’s revealed tubulointerstitial nephritis, tubular necrosis and obstruction. Treatment with NAC markedly improved oxidative stress parameters but did not show marked effect on dormex induced histopathological changes. Conclusions: It can be concluded that dormex triggers oxidative stress causing affection of the renal function. Although NAC could decrease oxidative stress, it was not able to protect against cellular toxicity of dormex.
Received in original form: 3 November 2021 Accepted in a final form: 15 Augest 2022
Keywords
Hydrogen cyanamide; Dormex; nephrotoxicity; Acetyl cysteine; oxidative stress
Statistics
Article View: 30
PDF Download: 19
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

Journal Management System. Designed by NotionWave.