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Ain Shams Journal of Forensic Medicine and Clinical Toxicology
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Volume Volume 39 (2022)
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Rashwan, M., Hilal, M., Elsayed, H., Mohamed, K., Allam, W. (2022). Experimental Study on Sub-acute Testicular Toxicity of AMB-FUBINACA in Adult Male Albino Rats. Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 39(2), 56-61. doi: 10.21608/ajfm.2022.249594
Mosab Rashwan; Maha Hilal; Hoda Elsayed; Khaled Mohamed; Walaa Allam. "Experimental Study on Sub-acute Testicular Toxicity of AMB-FUBINACA in Adult Male Albino Rats". Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 39, 2, 2022, 56-61. doi: 10.21608/ajfm.2022.249594
Rashwan, M., Hilal, M., Elsayed, H., Mohamed, K., Allam, W. (2022). 'Experimental Study on Sub-acute Testicular Toxicity of AMB-FUBINACA in Adult Male Albino Rats', Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 39(2), pp. 56-61. doi: 10.21608/ajfm.2022.249594
Rashwan, M., Hilal, M., Elsayed, H., Mohamed, K., Allam, W. Experimental Study on Sub-acute Testicular Toxicity of AMB-FUBINACA in Adult Male Albino Rats. Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2022; 39(2): 56-61. doi: 10.21608/ajfm.2022.249594

Experimental Study on Sub-acute Testicular Toxicity of AMB-FUBINACA in Adult Male Albino Rats

Article 7, Volume 39, Issue 2, July 2022, Page 56-61  XML PDF (1.54 MB)
Document Type: Original Article
DOI: 10.21608/ajfm.2022.249594
Authors
Mosab Rashwan1; Maha Hilal1; Hoda Elsayed2; Khaled Mohamed3; Walaa Allam1
1Forensic Medicine & Clinical Toxicology Department, Faculty of Medicine, Sohag University, Sohag, Egypt.
2Histology & Cell Biology, Faculty of Medicine, Sohag University, Sohag, Egypt.
3Chemistry, Naif Arab University for Security Sciences, Riyadh, KSA.
Abstract
Background: AMB-FUBINACA abuse was confirmed in case reports of a mass intoxication in the United States. Also it was reported that in New Zealand, there were at least 20 deaths related to the use of MMB-FUBINACA. Aim of the Work: To detect the toxic effect of synthetic cannabinoid (AMB-FUBINACA) with different doses on the testis of adult male albino rats histopathologically and Biochemically. Methods: the present work was conducted on 40 sexually mature male albino rats. Rats were divided into 5 groups 8 rats each as follow Group I: Negative control group, Group II: Positive control group where animals received ethanol 5%, Group III: Rats treated with AMB-FUBINACA at dose of 2.5 mg/kg dissolved in ethanol 5%, Group IV: Rats treated with AMB-FUBINACA at dose of 5 mg/kg dissolved in ethanol 5% and Group V: Rats treated with AMB-FUBINACA at dose of 10 mg/kg dissolved in ethanol 5% given by intraperitoneal injection for 4 weeks. Results: a significant decrease of testosterone level in AMB-FUBINACA treated groups compared to the control groups and degenerative changes in seminiferous tubules was also observed in treated groups. Conclusion: administration of AMB-FUBINACA for 4weeks was associated with toxic effects in testis
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